PUBLICATIONS

1. Oh YM, Bacallao EA, Lee SA, Kim J, Swinford S, Smith GE, Britt B, Abdalla SM, and Lee SW. Identification of age-associated upstream regulators to promote neuronal resilience in HD patient-derived neurons. Neurosci. Bull. 2026. Accepted.        

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2. Langfelder P, Wang M, Ramanathan L, Oh YM, Lee SW, Gao F, Gu X, Stricos M, Plascencia M, Vaca R, Richman J, Coppola G, Vogt T, Horvath S, Yoo AS, Aaronson J, Rosinski J, and Yang XW. Systematic Heterozygosity Perturbations Identify HD Transcriptomic and Pathological Modifiers Including Scn4b, Kcnh4, and FoxP1. BioRxive. 2026. In Revision. doi: https://doi.org/10.64898/2026.03.02.709091

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3. Lee SW, Upshaw TJ, Bailey DJ, Lee SA, Kim J, Joshi P, Smith GE, Swinford S, and Oh YM. CDKN1A Protects Medium Spiny Neurons from Huntington’s Disease Pathology. Neurobio. Dis. 2026. Sep. 227:107522. PMID: 42409247. https://doi.org/10.1016/j.nbd.2026.107522

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4. Lee K, Shin B, Kim M, Lee SW, Oh YM, Kim KH, Jiang A, Ko K, Gillis T, Lucente D, Lee R, Kwak S, Lee JM, Wheeler VC, Yoo AS, 

Gusella JF, MacDonald ME, and Seong IS. Genetic dissection of Huntington's disease modification by variation at RRM2B. Hum Mol Genet. 2025 Oct. 18;34(23):2004-2018. PMID: 41092345. https://doi.org/10.1093/hmg/ddaf150

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5. Oh YM*, and Lee SW*. Patient-derived neuron model: Capturing age-dependent adult-onset degenerative pathology in Huntington's disease. Mol Cells. 2024 Apr. 47(4):100046. *co-corresponding authors. PMID: 38492889. https://doi.org/10.1016/j.mocell.2024.100046

6. Oh YM*, Lee SW*, and Yoo AS. Striatal neuronal models of HD through direct-conversion: modeling age-dependent disease phenotypes. Elsevier books, Huntington’s Disease. 2024 Feb. Paperback ISBN: 9780323956727, eBook ISBN: 9780323956734. *co-first authors. https://doi.org/10.1016/B978-0-323-95672-7.00012-1

7. Lee SW*, Oh YM*, Victor MB, Yang Y, Chen S, Strunilin I, Dahiya S, Dolle RE, Pak SC, Silverman GA, Perlmutter DH, and Yoo AS. Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1–TFEB pathway to Huntington’s disease neurodegeneration. Nat. Aging. 2024 Jan. 4:95-109. *co-first authors. PMID: 38066314. https://doi.org/10.1038/s43587-023-00538-3

8. Oh YM*, Lee SW*, and Yoo AS. Modeling Huntington disease through microRNA-mediated neural reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration. Autophagy. 2023 Sep. 19(9):2613-2615. *co-first authors. PMID: 36727408. https://doi.org/10.1080/15548627.2023.2175572

9. Oh YM*, Lee SW*, Kim WK, Chen S, Church VA, Cates K, Li T, Zhang B, Dolle RE, Dahiya S, Pak SC, Silverman GA, Perlmutter DH, and Yoo AS. Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy. Nat. Neurosci. 2022 Nov. 25;1420-1433. *co-first authors. PMID: 36303071. https://doi.org/10.1038/s41593-022-01185-4

10. Lee SW, Oh YM, Lu Y, Kim WK, and Yoo AS. MicroRNAs overcome cell fate barrier by reducing EZH2-controlled REST stability during neuronal conversion of human adult fibroblasts. Dev. Cell. 2018 Jul. 2;73-4. PMID: 29974865. https://doi.org/10.1016/j.devcel.2018.06.007

11. Victor MB, Richner M, Olsen HE, Lee SW, Monteys AM, Ma C, Huh CJ, Zhang B, Davidson BL, Yang XW, and Yoo AS. Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat. Neurosci. 2018 Mar. 21:341-352. PMID: 29403030. https://doi.org/10.1038/s41593-018-0075-7

12. Abernathy DG, Kim WK, McCoy MJ, Lake AM, Ouwenga R, Lee SW, Xing X, Li D, Lee HJ, Heuckeroth RO, Dougherty JD, Wang T, and Yoo AS. MicroRNAs induce a permissive chromatin environment that enables neuronal subtype-specific reprogramming of adult human fibroblasts. Cell Stem Cell. 2017 Sep. 7;21(3):332-348.e9. PMID: 28886366. https://doi.org/10.1016/j.stem.2017.08.002  

13. Choi SG, Kim H, Jeong EI, Lee HJ, Park S, Lee SY, Lee HJ, Lee SW, Chung CH, and Jung YK. SUMO-modified FADD recruits cytosolic Drp1 and caspase-10 to mitochondria for regulated necrosis. Mol. Cell. Biol. 2017 Jan. 4;37(2). PMID: 27799292. https://doi.org/10.1128/MCB.00254-16

14. Park JH*, Lee SW*, Yang SW, Yoo HM, Park JM, Seong MW, Ka SH, Oh KH, Jeon YJ, and Chung CH. Modification of DBC1 by

SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage. Nat. Comm. 2014 Nov. 18;5:5483. *co-first authors. PMID: 25406032. https://doi.org/10.1038/ncomms6483

15. Yoo HM, Kang SH, Kim JY, Lee JE, Seong MW, Lee SW, Ka SH, Sou YS, Komatsu M, Tanaka K, Lee ST, Noh DY, Baek SH, Jeon YJ, and Chung CH. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Mol. Cell. 2014 Oct. 23;56(2):261-74. PMID: 25219498. https://doi.org/10.1016/j.molcel.2014.08.007

16. Park JM, Yang SW, Yu KR, Ka SH, Lee SW, Seol JH, Jeon YJ, and Chung CH. Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis. Mol. Cell. 2014 May. 22;54(4):626-38. PMID: 24768535. https://doi.org/10.1016/j.molcel.2014.03.031

17. Lee SW, Lee MH, Park JH, Kang SH, Yoo HM, Ka SH, Oh YM, Jeon YJ, and Chung CH. SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage. EMBO J. 2012 Nov. 28;31(23):4441-52. PMID: 23092970. https://doi.org/10.1038/emboj.2012.293

18. Lee SW, Seong MW, Jeon YJ, and Chung CH. Ubiquitin E3 ligases controlling p53 stability. Anim. Cells Syst. 2012 May. 16:173-182. https://doi.org/10.1080/19768354.2012.688769

19. Lee MH, Lee SW, Lee EJ, Choi SJ, Chung SS, Lee JI, Cho JM, Seol JH, Baek SH, Kim KI, Chiba T, Tanaka K, Bang OS, and Chung CH. SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination. Nat. Cell. Biol. 2006 Dec. 8(12):1424-31. PMID: 17086174. https://doi.org/10.1038/ncb1512